Austria

Large Language Models (LLMs) are transforming healthcare through LLM-based agents that can understand and assist with medical tasks. This survey examines the architectures, applications, and challenges of LLM-based agents in medicine. We analyze key components including system profiles, clinical planning, medical reasoning frameworks, and external capacity enhancement. The survey covers major applications in clinical decision support, medical documentation, training simulations, and healthcare service optimization, along with evaluation frameworks and metrics. While these agents show promise in enhancing healthcare delivery, challenges remain in hallucination management, multimodal integration, implementation, and ethics. We conclude by highlighting future directions in medical reasoning, physical system integration, and training simulations, providing researchers and practitioners with a structured overview of the field&#39;s current state and prospects.

ACL 2025

A Survey of LLM-based Agents in Medicine

healthcare applications

llm-based agents

medical ai

## Welcome!
"I am excited to welcome you to this year’s edition of the Conference on Empirical Methods in Natural Language Processing! Importantly, it marks the 30th edition of EMNLP. With over 8,000 submissions, more than 3,000 accepted papers, and thousands of attendees, we have come a long way from that first
workshop, which had 14 accepted papers. As the field looks ahead, Suzhou is the fitting location for celebrating this milestone: rooted in a long literary tradition, yet modern and forward-looking, and home to a large share of the NLP community." 

*Message from the General Chair, Dirk Hovy*

EMNLP 2025

Celebrate 30 Years of EMNLP! 
EMNLP 2025 will be held in Suzhou, China from November 5th to November 9th, 2025.

Large Language Models (LLMs) are transforming healthcare through LLM-based agents that can understand and assist with medical tasks. This survey examines the architectures, applications, and challenges of LLM-based agents in medicine. We analyze key components including system profiles, clinical planning, medical reasoning frameworks, and external capacity enhancement. The survey covers major applications in clinical decision support, medical documentation, training simulations, and healthcare service optimization, along with evaluation frameworks and metrics. While these agents show promise in enhancing healthcare delivery, challenges remain in hallucination management, multimodal integration, implementation, and ethics. We conclude by highlighting future directions in medical reasoning, physical system integration, and training simulations, providing researchers and practitioners with a structured overview of the field's current state and prospects.

poster

### Welcome to The 63rd Annual Meeting of the Association for Computational Linguistics (ACL 2025)

Message from the General Chair: 
*It is my great pleasure and honor to welcome you to the 63rd Annual Meeting of the Association for Computational Linguistics (ACL 2025), held in beautiful Vienna, Austria, from July 27 to August 1, 2025. ACL2025continues our field’s tradition of excellence in scholarship, innovation, and inclusivity, and I am deeply grateful to the many volunteers who have worked tirelessly to bring this event to life.* 
[Read more](https://drive.google.com/file/d/1GI_hvOpjswAuYdUTromfeDiPpCcqidwg/view?usp=sharing)

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Welcome to The 63rd Annual Meeting of the Association for Computational Linguistics (ACL 2025)

Long-context understanding is crucial for large language models (LLMs) and has become a fundamental capability for most LLMs. However, beyond the focus on "input-long", the ability to "output-long" is equally significant, yet it remains underexplored. To address this limitation, we propose a simple, efficient, and plug-in approach, Position ID Compression (PIC), to unlock the long-form text generation potential of LLMs. The idea is straightforward: by compressing the position ids of the context, we provoke and guide LLMs to generate coherent and longer output. Specifically, we find that directly reducing the position ids by a fixed ratio significantly impacts the generation quality. To mitigate this, we propose two variants of PIC: NTK-aware PIC and Dynamic PIC. Without additional training, both methods enable LLMs to extend their generation length by approximately 1.5 times without compromising generation quality. Furthermore, by integrating supervised fine-tuning (SFT) with PIC, we propose PIC-SFT, which further improves LLMs' long-form text generation capabilities, achieving top performance on HelloBench and LongBench-Write. Extensive experiments demonstrate the effectiveness of our approach.

PIC: Unlocking Long-Form Text Generation Capabilities of Large Language Models via Position ID Compression

RAG systems rely on rerankers to identify relevant documents. However, fine-tuning these models remains challenging due to the scarcity of annotated query-document pairs. Existing distillation-based approaches suffer from training-inference misalignment and fail to capture interdependencies among candidate documents. To overcome these limitations, we reframe the reranking process as an attention-mask problem and propose Gumbel Reranking, an end-to-end training framework for rerankers aimed at minimizing the training-inference gap. In our approach, reranker optimization is reformulated as learning a stochastic, document-wise Top-$k$ attention mask using the Gumbel Trick and Relaxed Top-$k$ Sampling. This formulation enables end-to-end optimization by minimizing the overall language loss. Experiments across various settings consistently demonstrate performance gains, including a 10.4% improvement in recall on HotpotQA for distinguishing indirectly relevant documents.

Gumbel Reranking: Differentiable End-to-End Reranker Optimization

Knowledge neuron theory provides a key approach to understanding the mechanisms of factual knowledge in Large Language Models (LLMs), which suggests that facts are stored within multi-layer perceptron neurons. This paper further explores **Degenerate Knowledge Neurons** (DKNs), where distinct sets of neurons can store identical facts, but unlike simple redundancy, they also participate in storing other different facts. Despite the novelty and unique properties of this concept, it has not been rigorously defined and systematically studied. Our contributions are: (1) We pioneer the study of structures in knowledge neurons by analyzing weight connection patterns, providing a comprehensive definition of DKNs from both functional and structural aspects. (2) Based on this definition, we develop the **Neuronal Topology Clustering** method, leading to a more accurate DKN identification. (3) We demonstrate the practical applications of DKNs in two aspects: guiding LLMs to learn new knowledge and relating to LLMs' robustness against input errors.

Cracking Factual Knowledge: A Comprehensive Analysis of Degenerate Knowledge Neurons in Large Language Models

We demonstrate that features, rather than neurons, serve as superior analytical units for understanding the mechanisms of factual knowledge in Language Models (LMs). Previous studies primarily utilize MLP neurons as units of analysis; however, neurons suffer from polysemanticity, leading to limited knowledge expression and poor interpretability. We first conduct preliminary experiments to validate that SAE can effectively decompose neurons into features. With this established, our core findings reveal three key advantages of features over neurons: (1) Features exhibit stronger influence on knowledge expression and superior interpretability. (2) Features demonstrate enhanced monosemanticity, showing distinct activation patterns between related and unrelated facts. (3) Feature-based method demonstrates superior performance over neuron-based approaches in erasing privacy-sensitive information from LMs. Additionally, we propose FeatureEdit, the first feature-based editing method. Code and dataset will be available.

The Knowledge Microscope: Features as Better Analytical Lenses than Neurons

Knowledge Graph Embedding (KGE) is a common approach for Knowledge Graphs (KGs) in AI tasks. Embedding dimensions depend on application scenarios. Requiring a new dimension means training a new KGE model from scratch, increasing cost and limiting efficiency and flexibility. In this work, we propose a novel KGE training framework MED. It allows one training to obtain a croppable KGE model for multiple scenarios with different dimensional needs. Sub-models of required dimensions can be directly cropped and used without extra training. In MED, we propose a mutual learning mechanism to improve the low-dimensional sub-models and make high-dimensional sub-models retain the low-dimensional sub-models' capacity, an evolutionary improvement mechanism to promote the high-dimensional sub-models to master the triple that the low-dimensional sub-models can not, and a dynamic loss weight to adaptively balance the multiple losses. Experiments on 4 KGE models across 4 standard KG completion datasets, 3 real-world scenarios using a large-scale KG, and extending MED to the BERT language model demonstrate its effectiveness, high efficiency, and flexible extensibility.

Croppable Knowledge Graph Embedding

Automatically generating high-quality mathematical problems that align with educational objectives is a crucial task in NLP-based educational technology. Traditional generation methods focus primarily on textual quality, but they often overlook educational objectives. Moreover, these methods address only single-dimensional, simple question generation, failing to meet complex, multifaceted educational requirements. To address these challenges, we constructed and annotated EduMath, a dataset of 16k mathematical questions with multi-dimensional educational objectives. Based on this dataset, we developed EQGEVAL, which incorporates three evaluation dimensions and is designed to assess the ability of models to generate educational questions. Drawing inspiration from teachers' problem design processes, we propose the Educational Question Planning with self-Reflection (EQPR) method for educational mathematical question generation, following a "plan-evaluate-optimize" approach. Specifically, by combining planning algorithm based on Monte Carlo Tree Search with the generative capabilities of Large Language Models, we continuously optimize questions through iterative feedback. This self-optimization mechanism ensures that the generated questions both fit the educational context and strategically achieve specific basic educational objectives. Through extensive experiments based on EQGEVAL, we have demonstrated that EQPR achieves significant improvements in generating questions that meet multi-dimensional educational objectives.

From Objectives to Questions: A Planning-based Framework for Educational Mathematical Question Generation

Simultaneous speech translation (SST) outputs translations in parallel with streaming speech input, balancing translation quality and latency. While large language models (LLMs) have been extended to handle the speech modality, streaming remains challenging as speech is pre-pended as a prompt for the entire generation process. To unlock LLM streaming capability, this paper proposes SimulS2S-LLM, which trains speech LLMs offline and employs a test-time policy to guide simultaneous inference. SimulS2S-LLM alleviates the mismatch between training and inference by extracting boundary-aware speech prompts that allows it to be better matched with text input data. SimulS2S-LLM achieves simultaneous speech-to-speech translation (Simul-S2ST) by predicting discrete output speech tokens and then synthesising output speech using a pre-trained vocoder. An incremental beam search is designed to expand the search space of speech token prediction without increasing latency. Experiments on the CVSS speech data show that SimulS2S-LLM offers a better translation quality-latency trade-off than existing methods that use the same training data, such as improving ASR-BLEU scores by 3 points at similar latency.

SimulS2S-LLM: Unlocking Simultaneous Inference of Speech LLMs for Speech-to-Speech Translation

Supervised fine-tuning (SFT) has enabled large language models (LLMs) to exhibit promising performance on various tasks. However, this fine-tuning process only compares current predictions and labels on each sample, yet fails to perceive and understand its error outputs from different degrees, which may potentially produce a large percentage of serious errors. This poses a problem for aspect-based sentiment analysis (ABSA) in that these serious errors bring a greater negative impact than acceptable ones. Humans tend to compare mistakes to understand the varying degrees of mistakes, thus avoiding major bad decisions. Inspired by this, we propose a simple yet effective framework that could perceive and understand the degree of different errors by learning from comparative error pairs. It utilizes the SFT model to yield multiple outputs on each sample and selects acceptable and severe errors based on the acceptable scores. Together with the labels, we construct two comparative error pairs and exploit their calibration losses to optimize parameters. We conduct comprehensive experiments on ABSA datasets to demonstrate the effectiveness of our framework over baselines.

Error Comparison Optimization for Large Language Models on Aspect-Based Sentiment Analysis

Tool learning has emerged as a promising direction by extending Large Language Models’ (LLMs) capabilities with external tools. Existing tool learning studies primarily focus on the general-purpose tool-use capability, which addresses explicit user requirements in instructions. However, they overlook the importance of personalized tool-use capability, leading to an inability to handle implicit user preferences. To address the limitation, we first formulate the task of personalized tool learning, which integrates user’s interaction history towards personalized tool usage. To fill the gap of missing benchmarks, we construct PEToolBench, featuring diverse user preferences reflected in interaction history under three distinct personalized settings, and encompassing a wide range of tool-use scenarios. Moreover, we propose a framework PEToolLLaMA to adapt LLMs to the personalized tool learning task, which is trained through supervised fine-tuning and direct preference optimization. Extensive experiments on PEToolBench demonstrate the superiority of PEToolLLaMA over existing LLMs. We release code and data for review at https://anonymous.4open.science/r/PEToolBench-952F/.

PEToolLLM: Towards Personalized Tool Learning in Large Language Models

Large language model training follows a standard pipeline: tokenization, pretraining, possibly mid-training, and post training or alignment. Despite its wild success, we understand relatively little about this recipe and are almost certainly missing many opportunities to improve it. In this talk, I will focus on three such cases. I’ll describe our work on data efficient post training (e.g. LIMA, ALMA, and s1) where we argue that nearly all advanced model capabilities ultimately come from the pretraining data, even if effective alignment is still essential for controlling model behavior. I will also describe new methods for extracting more signal from the pretraining data, including new hierarchical architectures for byte-level language models (e.g. BLT) that are both tokenizer-free and scale better than traditional BPE-based methods, especially in the long tail. Finally, I will discuss decentralized, modular training algorithms (e.g. BTM) that better isolate and control the influence of specific data on specific model components and behaviors. Together, these methods promise to simplify training and improve scaling, by centering and amplifying the influence of data in architecture design.

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