Thailand

Large Language Models (LLMs) have demonstrated remarkable versatility in recent years, offering potential applications across specialized domains such as healthcare and medicine. Despite the availability of various open-source LLMs tailored for health contexts, adapting general-purpose LLMs to the medical domain presents significant challenges.
In this paper, we introduce BioMistral, an open-source LLM tailored for the biomedical domain, utilizing Mistral as its foundation model and further pre-trained on PubMed Central. We conduct a comprehensive evaluation of BioMistral on a benchmark comprising 10 established medical question-answering (QA) tasks in English. We also explore lightweight models obtained through quantization and model merging approaches. Our results demonstrate BioMistral&#39;s superior performance compared to existing open-source medical models and its competitive edge against proprietary counterparts. Finally, to address the limited availability of data beyond English and to assess the multilingual generalization of medical LLMs, we automatically translated and evaluated this benchmark into 7 other languages. This marks the first large-scale multilingual evaluation of LLMs in the medical domain. Datasets, multilingual evaluation benchmarks, scripts, and all the models obtained during our experiments are freely released.

ACL 2024

BioMistral: A Collection of Open-Source Pretrained Large Language Models for Medical Domains

biomistral

mistral

quantization

healthcare

health

language modeling

medical

question answering

### Welcome!
The 62nd Annual Meeting of the Association for Computational Linguistics (ACL 2024) will take place in Bangkok, Thailand from August 11th to 16th, 2024. Our Virtual Poster Sessions will take place online Thursday, August 22, 2024.

You are required to register for this event. **Please register [here](https://2024.aclweb.org/registration). **

If you have already registered, please check your inbox for an email from Underline granting you access to ACL 2024 content.

Please register!

The 62nd Annual Meeting of the Association for Computational Linguistics (ACL 2024) will take place in Bangkok, Thailand from August 11th to 16th, 2024. More information will be announced soon.

Large Language Models (LLMs) have demonstrated remarkable versatility in recent years, offering potential applications across specialized domains such as healthcare and medicine. Despite the availability of various open-source LLMs tailored for health contexts, adapting general-purpose LLMs to the medical domain presents significant challenges.
In this paper, we introduce BioMistral, an open-source LLM tailored for the biomedical domain, utilizing Mistral as its foundation model and further pre-trained on PubMed Central. We conduct a comprehensive evaluation of BioMistral on a benchmark comprising 10 established medical question-answering (QA) tasks in English. We also explore lightweight models obtained through quantization and model merging approaches. Our results demonstrate BioMistral's superior performance compared to existing open-source medical models and its competitive edge against proprietary counterparts. Finally, to address the limited availability of data beyond English and to assess the multilingual generalization of medical LLMs, we automatically translated and evaluated this benchmark into 7 other languages. This marks the first large-scale multilingual evaluation of LLMs in the medical domain. Datasets, multilingual evaluation benchmarks, scripts, and all the models obtained during our experiments are freely released.

poster

We introduce a novel dataset tailored for code generation, aimed at aiding developers in common tasks. Our dataset provides examples that include a clarified intent, code snippets associated, and an average of three related unit tests. It encompasses a range of libraries such as \texttt{Pandas}, \texttt{Numpy}, and \texttt{Regex}, along with more than 70 standard libraries in Python code derived from Stack Overflow. Comprising 3,402 crafted examples by Python experts, our dataset is designed for both model finetuning and standalone evaluation. To complete unit tests evaluation, we categorize examples in order to get more fine grained analysis, enhancing the understanding of models' strengths and weaknesses in specific coding tasks. The examples have been refined to reduce data contamination, a process confirmed by the performance of three leading models: Mistral 7B, CodeLLAMA 13B, and Starcoder 15B. We further investigate data-contamination testing GPT-4 performance on a part of our dataset. The benchmark can be accessed at \texttt{anonymized address}.

CodeInsight: A Curated Dataset of Practical Coding Solutions from Stack Overflow

For multilingual training, we present CrossInit, an initialization method that initializes embeddings into similar geometrical structures across languages in an unsupervised manner. CrossInit leverages a common cognitive linguistic mechanism, Zipf’s law, which indicates that similar concepts across languages have similar word ranks or frequencies in their monolingual corpora. Instead of considering point-to-point alignments based on ranks, CrossInit considers the same span of consecutive ranks in each language as the Positive pairs for alignment, while others out of the span are used as Negative pairs. CrossInit then employs Contrastive Learning to iteratively refine randomly initialized embeddings for similar geometrical structures across languages. Our experiments on Unsupervised NMT, XNLI, and MLQA showed significant gains in low-resource and dissimilar languages after applying CrossInit.

Zero-shot Cross-lingual Alignment for Embedding Initialization

Large Vision-Language Models (LVLMs) are an extension of Large Language Models (LLMs) that facilitate processing both image and text inputs, expanding AI capabilities. However, LVLMs struggle with object hallucinations due to their reliance on text cues and learned object co-occurrence biases. While most research quantifies these hallucinations, mitigation strategies are still lacking. Our study introduces a Language Contrastive Decoding (LCD) algorithm that adjusts LVLM outputs based on LLM distribution confidence levels, effectively reducing object hallucinations. We demonstrate the advantages of LCD in leading LVLMs, showing up to \%4 improvement in POPE F1 scores and up to \%36 reduction in CHAIR scores on the COCO validation set, while also improving captioning quality scores. Our method effectively improves LVLMs without needing complex post-processing or retraining, and is easily applicable to different models. Our findings highlight the potential of further exploration of LVLM-specific decoding algorithms.

Mitigating Hallucinations in Large Vision-Language Models (LVLMs) via Language-Contrastive Decoding (LCD)

We address the open problem of automatically identifying the direction of lexical borrowing, given word pairs in the donor and recipient languages. We propose strong benchmarks for this task, by applying a set of machine learning models. We extract and publicly release a comprehensive borrowings dataset from the recent RoBoCoP cognates and borrowings database for five Romance languages. We experiment on this dataset with both graphic and phonetic representations and with different features, models and architectures. We interpret the results, in terms of F1 score, commenting on the influence of features and model choice, of the imbalanced data and of the inherent difficulty of the task for particular language pairs. We show that automatically determining the direction of borrowing is a feasible task, and propose additional directions for future work.

It takes two to borrow: a donor and a recipient. Who’s who?

Recently, advancements in large language models (LLMs) have shown an unprecedented ability across various language tasks. This paper investigates the potential application of LLMs to slot filling with noisy ASR transcriptions, via both in-context learning and task-specific fine-tuning. Dedicated prompt designs and noise-robust LoRA fine-tuning are proposed to improve the robustness of LLMs for slot filling with noisy ASR transcriptions. Moreover, a linearised knowledge injection (LKI) scheme is also proposed to integrate dynamic external knowledge into LLMs. Experiments were performed on SLURP to quantify the performance of LLMs, including GPT-3.5-turbo, GPT-4, LLaMA-13B, LLaMA-2-13B and Vicuna-13B (v1.1 and v1.5) with different ASR error rates. The use of the noise-robust fine-tuning together with LKI for Vicuna-13B-v1.5 achieved 6.7% and 17.6% absolute SLU-F1 improvements compared to a fully fine-tuned Flan-T5-XL model on the limited data setup and the zero-shot setup respectively.

Speech-based Slot Filling using Large Language Models

In-context learning has become a popular paradigm in natural language processing. However, its performance can be significantly influenced by the order of in-context demonstration examples. In this paper, we found that causal language models (CausalLMs) are more sensitive to this order compared to prefix language models (PrefixLMs). We attribute this phenomenon to the auto-regressive attention masks within CausalLMs, which restrict each token from accessing information from subsequent tokens. This results in different receptive fields for samples at different positions, thereby leading to representation disparities across positions. To tackle this challenge, we introduce an unsupervised fine-tuning method, termed the Information-Augmented and Consistency-Enhanced approach. This approach utilizes contrastive learning to align representations of in-context examples across different positions and introduces a consistency loss to ensure similar representations for inputs with different permutations. This enhances the model's predictive consistency across permutations. Experimental results on five benchmarks suggest that our proposed method can reduce the sensitivity of CausalLMs to the order of in-context examples and exhibit robust generalizability, particularly when demonstrations are sourced from a candidate pool different from that used in the training phase, or when the number of in-context examples differs from what is used during training.

Addressing Order Sensitivity of In-Context Demonstration Examples in Causal Language Models

In many practical scenarios, contents from different modalities are not semantically aligned; for instance, visual and textual information may conflict with each other, resulting in non-compositional expression effects such as irony or humor. Effective modeling and smooth integration of multimodal information are crucial for achieving good understanding of the contrast across modalities. Being focusing on image-text matching, most current studies face challenges in identifying such contrast, leading to limitations in exploring the extended semantics when images and texts do not match. In this paper, we propose an LLM-based approach for learning multimodal contrast following the encoding-decoding paradigm, enhanced by a memory module with reinforced contrast recognition, and use a series of tasks that have the nature of multimodal contrast to verify our approach. The memory module learns the integration between visual and textual features with trainable memory vectors and the reinforced contrast recognition uses self-rejection sampling to optimize the memory to further enhance learning multimodal contrast. The resulted information, accompanied with visual and text features, is finally fed into the LLM to predict corresponding labels. We experiment our approach on four English and Chinese benchmark datasets, where it outperforms strong baselines and state-of-the-art studies.

Learning Multimodal Contrast with Cross-modal Memory and Reinforced Contrast Recognition

This research introduces a Positive Reconstruction Framework based on positive psychology theory. Overcoming negative thoughts can be challenging, our objective is to address and reframe them through a positive reinterpretation. To tackle this challenge, a two-fold approach is necessary: identifying cognitive distortions and suggesting a positively reframed alternative while preserving the original thought's meaning. Recent studies have investigated the application of Natural Language Processing (NLP) models in English for each stage of this process. In this study, we emphasize the theoretical foundation for the Positive Reconstruction Framework, grounded in broaden-and-build theory. We provide a shared corpus containing 4001 instances for detecting cognitive distortions and 1900 instances for positive reconstruction in Mandarin. Leveraging recent NLP techniques, including transfer learning, fine-tuning pretrained networks, and prompt engineering, we demonstrate the effectiveness of automated tools for both tasks. In summary, our study contributes to multilingual positive reconstruction, highlighting the effectiveness of NLP in cognitive distortion detection and positive reconstruction.

Detection and Positive Reconstruction of Cognitive Distortion Sentences: Mandarin Dataset and Evaluation

Verifying a question's validity before answering is crucial in real-world applications, where users may provide imperfect instructions. In this scenario, an ideal model should address the discrepancies in the query and convey them to the users rather than generating the best possible answer. Addressing this requirement, we introduce a new compositional visual question-answering dataset, VisReas, that consists of answerable and unanswerable visual queries formulated by traversing and perturbing commonalities and differences among objects, attributes, and relations. VisReas contains 2.07M semantically diverse queries generated automatically using Visual Genome scene graphs. The unique feature of this task, validating question answerability with respect to an image before answering, and the poor performance of state-of-the-art models inspired the design of a new modular baseline, Logic2Vision that reasons by producing and executing pseudocode without any external modules to generate the answer. Logic2Vision outperforms generative models in VisReas (+4.82% over LLaVA-1.5; +12.23% over InstructBLIP) and achieves a significant gain in performance against the classification models.

VISREAS: Complex Visual Reasoning with Unanswerable Questions

Object hallucination has been an Achilles' heel which hinders the broader applications of large vision-language models (LVLMs). Object hallucination refers to the phenomenon that the LVLMs claim non-existent objects in the image. To mitigate the object hallucinations, instruction tuning and external model-based detection methods have been proposed, which either require large-scare computational resources or depend on the detection result of external models. However, there remains an under-explored field to utilize the LVLM itself to alleviate object hallucinations. In this work, we adopt the intuition that the LVLM tends to respond logically consistently for existent objects but inconsistently for hallucinated objects. Therefore, we propose a Logical Closed Loop-based framework for Object Hallucination Detection and Mitigation, namely $\textbf{LogicCheckGPT}$. In specific, we devise logical consistency probing to raise questions with logical correlations, inquiring about attributes from objects and vice versa. Whether their responses can form a logical closed loop serves as an indicator of object hallucination. As a plug-and-play method, it can be seamlessly applied to all existing LVLMs. Comprehensive experiments conducted on three benchmarks across four LVLMs have demonstrated significant improvements brought by our method, indicating its effectiveness and generality.

Downloads

Next from ACL 2024

CodeInsight: A Curated Dataset of Practical Coding Solutions from Stack Overflow

Similar lecture

MedExQA: Medical Question Answering Benchmark with Multiple Explanations

Stay up to date with the latest Underline news!

PRODUCT

COMPANY

RESOURCES